- 30-11-2022Next Generation Risk Assessment (NGRA) can use the Dietary Comparator Ratio (DCR) to evaluate the safety of a defined exposure…
- 30-11-2022CORT118335 (miricorilant) is a GR ligand that acts as a selective modulator of GR activity by inducing a combination of…
- 29-11-2022BackgroundMedullary thyroid carcinoma (MTC) is a neuroendocrine tumor derived from the parafollicular C-cells of the thyroid gland. In patients with…
- 29-11-2022Introduction:Adrenocortical carcinoma (ACC) is a rare but aggressive malignancy with limited treatment options so far. Possible treatments are usually studied…
- 29-11-2022The androgen receptor (AR) and the glucocorticoid receptor (GR) have a very similar mechanism of action. Despite these similarities, androgens…
- 28-11-2022The Farnesoid-X-Receptor (FXR) is a transcription factor activated by bile acids, which acts as a metabolic homeostat for lipids, glucose and…
- 28-11-2022Purpose: Corticosteroids are a major risk factor for central serous chorioretinopathy (CSC), a posterior eye disease with a poorly understood…
- 21-11-2022Cushing’s Syndrome (CS) is caused by the pathological dysregulation of glucocorticoid (GC) hormone secretion. Although surgery remains the first-line treatment…
- 17-11-2022Objectives. Long-term glucocorticoid levels measured in scalp hair (HairGCs), including hair cortisol and its inactive form hair cortisone, are frequently…
- 17-11-2022Peroxisome proliferator-activated receptor g (PPARg), a member of the nuclear receptor superfamily of ligand inducible transcription factors, is viewed as…
