- 15-11-2023Background:Pathogenic variants in the LRP5, PLS3, or WNT1 genes can significantly affect bone mineral density, causing monogenic osteoporosis. Much remains to be discovered…
- 15-11-2023ABSTRACTIntroduction: The combination of disease manifestations, a familial burden and the rare genetic etiology serve a unique impact on Quality…
- 15-11-2023ABSTRACTIntroduction: The combination of disease manifestations, a familial burden and the rare genetic etiology serve a unique impact on Quality…
- 15-11-2023BackgroundThe Farnesoid X Receptor (FXR) is a nuclear receptor activated by bile acids. Upon activation, FXR regulates transcription of genes…
- 15-11-2023Amidst the continuum of internal and external changes associated with aging, there is a persistent decline in bone mass and…
- 15-11-2023Amidst the continuum of internal and external changes associated with aging, there is a persistent decline in bone mass and…
- 15-11-2023Background: Adrenocortical carcinoma (ACC) is a rare but devastating malignancy (5-year survival 18-57%), with limited treatment options. Currently mitotane is…
- 15-11-2023The Farnesoid X Receptor (FXR) is a nuclear receptor activated by bile acids, which acts as a metabolic homeostat for…
- 15-11-2023Endocrine therapies effectively treat breast cancer (BC), but resistance to treatment is common. Currently, 214 clinical trials are registered to…
- 15-11-2023Disrupted thyroid hormone (TH) homeostasis has devastating effects on human neurodevelopment. THs are critical signaling molecules in neurodevelopment, acting on…
