- 13-11-2023Obesity is closely associated with reproductive disorders, including polycystic ovary syndrome (PCOS) and infertility. Diet-induced obesity in female mice has…
- 10-11-2023Introduction: The hypothalamic paraventricular nucleus (PVN) is a highly complex brain region that is crucial for homeostatic regulation through neuroendocrine…
- 10-11-2023Background/aim: Central serous chorioretinopathy (CSC) is a posterior eye disease with corticosteroids as a risk factor and characterized by choroidal…
- 03-11-2023Innate immune cells, including macrophages, are functionally affected by thyroid hormone (TH). Macrophages can undergo phenotypical alterations, shifting between pro-inflammatory…
- 31-10-2023BackgroundEndogenous steroid hormones have significant effects on inflammatory and immune processes, but the immunological activities of steroidogenesis precursors remain largely…
- 31-10-2023CORT118335 (miricorilant) and CORT125385 are structurally similar selective GR modulators (SGRMs) that combine GR agonism and antagonism and were previously…
- 03-09-2023Introduction: Brown adipose tissue (BAT) combusts lipids and glucose to generate heat. Via this process of non-shivering thermogenesis, BAT plays a…
- 03-09-2023Innate immune cells, including macrophages, are functionally affected by thyroid hormone (TH). Macrophages can undergo phenotypical alterations, shifting between pro-(M1)…
- 02-09-2023Background: Non-alcoholic fatty liver disease (NAFLD) comprises a spectrum ranging from hepatosteatosis through steatohepatitis to fibrosis and irreversible cirrhosis. Previously,…
- 01-09-2023Research plan: Cost-effectiveness of newborn screening for X-linked adrenoleukodystrophy (ALD) in the NetherlandsRosalie Martens, Marc Engelen, Stephan Kemp, Anita Boelen,…
